HCID 58913148, compound → HCID 58913146, compound

Participants

Reaction Steps

A solution of 2-benzenesulfonyl-7-(4-tert-butoxycarbonyl-piperazin-1-yl)-indole-1-carboxylic acid tert butyl ester 1-4 (160 mg, 0.3 mmol) in isopropanol (15 mL) and concentrated HCl (4 mL) was refluxed for 1 hour. The reaction mixture was concentrated and the remaining powder was triturated with isopropanol (10 mL) and ether (20 mL). This was filtered to afford 2-benzenesulfonyl-7-piperazin-1-yl-1H-indole, Compound 1 of Table 1 as a white solid (90 mg, 89%). M+H=342.

Provenance & Evidence