Piperazine → HCID 131723977, compound

Participants

Reaction Steps

The title compound was prepared according to the procedure of example 4, step 2 starting from the product of step 1 above (0.49 g), piperazine (0.86 g, 10 mmol) and K2CO3 (1.00 g, 7.2 mmol). This gave the free base of the title compound as an oil. Yield 0.43 g (73%). The free base was dissolved in ethyl ether and a solution of HCl in diethyl ether was added until no more precipitate was formed. The precipitate was collected, washed with diethyl ether, and dried in vaccum to give 0.41 g (56%) of the title compound: mp 171-173° C.). HRMS m/z calcd for C16H20N4O2 (M)+ 300.1586, found 300.1586. Anal. (C16H20N4O2.2HCl) C, H, N.

Provenance & Evidence