HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 18186829, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(Trifluoromethyl)benzenemethanol | HCID 67684 | — |
| Reactant | 2,6-Dichloropyrazine | HCID 78504 | — |
| Product | HCID 18186829 | HCID 18186829 | 93.5% |
Reaction Steps
The title compound was prepared according to the procedure of example 4, step 1 starting from 2,6-dichloropyrazine (444 mg, 3.00 mmol) and 4-trifluoromethylbenzyl alcohol (581 mg, 3.30 mmol) and NaH (55% in mineral oil, 144 mg, 3.30 mmol). Recrystallization from hexane gave 0.81 g (93%) of the title compound: mp 67-69° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07247633B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-985d9d040b904d8697e762cff2b25ccc |
| Source note | uspto-grants-2007_07 |