Benzyl Alcohol → HCID 68574100, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2S)-1-(6-chloro-2-pyrazinyl)-2-methylpiperazine (prepared in step 2 above; 0.16 g, 0.72 mmol) and benzyl alcohol (0.12 g, 1.1 mmol) in DMF (4 mL) was Na-t-BuO (0.14 g, 1.4 mmol) added and the mixture was stirred at 150° C. overnight. The solvent was evaporated off under reduced pressure and the residue taken up between CHCl3/H2O. The organic phase was concentrated and the crude product was purified by preparative C18-HPLC using acetonitrile/H2O/HOAc with UV detection at 254 nm. Yield: 1 mg (0.4%). MS m/z 284 (M)+. HRMS m/z calcd for C16H20N4O (M)+ 284.1637, found 284.1640.

Provenance & Evidence