Piperazine → 2-(4-Phenoxybutoxy)-6-(1-Piperazinyl)Pyrazine

Participants

Reaction Steps

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-(4-phenoxybutoxy)pyrazine (1.99 g, 7.14 mmol; obtained according to the procedure of example 50, step 1, starting from 4-phenoxy-1-butanol*), piperazine (1.84 g, 21.4 mmol) and K2CO3 (0.99 g, 7.14 mmol). The yield of the title compound was 1.52 g (65%) which was obtained as an oil. Purity 100% (HPLC). MS m/z 329 (M+H)+. HRMS m/z calcd for C18H24N4O2 (M)+ 328.1899, found 328.1894. *Prepared by reduction (LiAlH4) of the corresponding acid (cf J. Org. Chem. 1965, 30, 2441-2447; ibid. 1968, 33, 2271-2284).

Provenance & Evidence