2,6-Dichloropyrazine → HCID 18186804, compound

HRID 1296659Notes

Reaction equation

HRID 1296659 reaction equation
[N:1]1([C:6]2[CH:10]=[CH:9][S:8][C:7]=2[CH2:11][OH:12])[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl:13][C:14]1[CH:19]=[N:18][CH:17]=[C:16](Cl)[N:15]=1>>[Cl:13][C:14]1[CH:19]=[N:18][CH:17]=[C:16]([O:12][CH2:11][C:7]2[S:8][CH:9]=[CH:10][C:6]=2[N:1]2[CH:2]=[CH:3][CH:4]=[CH:5]2)[N:15]=1

Participants

3

Reactant 2

HCID 785042,6-DichloropyrazineHCID 3424643-(Pyrrol-1-Yl)Thiophene-2-Methanol

Product 1

HCID 18186804HCID 18186804, compound

Procedure

The title compound was prepared according to the procedure of example 50, step 1, starting from 3-(pyrrol-1-yl)thiophene-2-methanol (2.5 g, 14 mmol), K-t-BuO (1.43 g, 12.7 mmol) and 2,6-dichloropyrazine (1.73 g, 11.6 mmol). The yield of the title compound was 3.05 g (90%) and was obtained as an oil. Anal. (C13H10ClN3OS) C, H, N.

Workup

  1. customThe title compound was prepared
  2. customwas obtained as an oil

Sources & evidence

ORD record
ord-f26e3b114b564498b71c412f52d002eb
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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