HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1296678Generated: October 31, 2026
Hydroxyphenylacetic acid → 1-(2-Hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)ethanone
https://huagongshe.com/reaction/1296678
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydroxyphenylacetic acid | HCID 127 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 1-(2-Hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)ethanone | HCID 14920056 | — |
Reaction Steps
A suspension of 3-methoxyphenol (44.69 kg, 360 mol) and 4-hydroxyphenylacetic acid (68.5 kg, 450 mol) in 144 L of chlorobenzene was purged with nitrogen gas. Boron trifluoride diethyl etherate (177 L, 1440 mol) was added at 20 to 25° C. The suspension was heated to 80° C. and stirred for 4 to 5 h then cooled to 5 to 10° C. and stirred overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07247646B2 |
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| Source dataset | uspto-grants-2007_07 |
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| ORD ID | ord-812a7c43911943f2a8928f8599859abe |
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| Source note | uspto-grants-2007_07 |
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