Potassium Carbonate → HCID 58913125, compound

Participants

Reaction Steps

A mixture of 2,2-dimethyl-propionic acid 4-(6-bromo-7-methoxy-2-oxo-3-(4-trifluoromethyl-phenyl)-2H-chromen-4-ylmethyl)-phenyl ester (100 mg, 0.17 mmol), K2CO3 (70 mg, 0.51 mmol), trimethylboroxine (24 μL, 0.17 mmol) and Pd(Ph3P)4 (20 mg, 0.017 mmol) in anhydrous dioxane (2 mL) was stirred at reflux temperature for 2 h. After cooling to room temperature, the resultant suspension was filtered over Celite, and the solvent was removed in vacuo. The residue was recrystallized from CH2Cl2/hexane to afford the desired compound as a beige solid (72 mg, 82%) displaying. 1H NMR (300 MHz, CDCl3) δ 7.62 (d, J=8.0 Hz, 2H), 7.36 (d, J=8.0 Hz, 2H), 7.22 (d, J=0.9 Hz, 1H), 7.04 (d, J=8.8 Hz, 2H), 6.96 (d, J=8.8 Hz, 2H), 6.83 (s, 1H), 4.02 (s, 2H), 3.91 (s, 3H), 2.16 (s, 3H), 1.35 (s, 9H); MS (ESI) m/z 524.9 (M+H)+, HPLC tR 7.81 min.

Provenance & Evidence