HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxyphenylacetic acid → 1-(2-Hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxyphenylacetic acid | HCID 127 | — |
| Reactant | Boron trifluoride etherate | HCID 8000 | — |
| Reactant | 3-Methoxyphenol | HCID 9007 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 1-(2-Hydroxy-4-methoxyphenyl)-2-(4-hydroxyphenyl)ethanone | HCID 14920056 | — |
Reaction Conditions
| Temperature | 7.5 °C |
|---|
Reaction Steps
A suspension of 3-methoxyphenol (44.69 kg, 360 mol) and 4-hydroxyphenylacetic acid (68.5 kg, 450 mol) in 144 L of chlorobenzene was purged with nitrogen gas. Boron trifluoride diethyl etherate (177 L, 1440 mol) was added at 20 to 25° C. The resultant suspension was heated to 80° C., stirred for 4 to 5 h, cooled to 5 to 10° C. and stirred overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07247646B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-8e508067939f4ac5a45a7ebddbf1c416 |
| Source note | uspto-grants-2007_07 |