反应详情

温度

160 °C

N-Cyclopentyl-8-(2-fluoro-4-pyridiny)-2-(methylsulfanyl)-7-phenylpyrazolo[1,5-a][1,3,5]triazin -4amine 60 mg, 0.14 mmol) was dissolved in cyclopentylamine and heated at 160° C. in a glass pressure vessel for 24 hours. The resulting solution was concentrated in vacuo to give a residue that was purified by silica gel chromatography (ethyl acetate:hexane 1:1 to ethyl acetate) to yield 25 mg (34%) of N2,N4-dicyclopentyl-8-[2-(cyclopentylamino)-4-pyridinyl]-7-phenylpyrazolo[1,5-a][1,3,5]triazine-2,4-diamine as a foam. 1H-NMR (CDCl3): δ 7.94 (d, 1H), 7.60 (m, 2H), 7.45 (m, 3H), 6.81 (d, 1H), 6.36 (m, 1H), 5.13 (d, 1H), 4.60 (m, 1H), 4.44 (m, 2H), 3.74 (m, 1H), 2.1–1.4 (m, 24H); MS m/z 523 (M+1).

1. concentrationThe resulting solution was concentrated in vacuo
2. customto give a residue that
3. customwas purified by silica gel chromatography (ethyl acetate:hexane 1:1 to ethyl acetate)