Potassium Carbonate → 3-{[2-[(3,5-Dimethoxy-4-methyl-benzoylamino)-methyl]-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenylamino]-methyl}-benzoic acid methyl ester

Participants

Reaction Conditions

Reaction Steps

A suspension of compound 1g (76 mg, 0.20 mmol), methyl-3-(bromomethylbenzoate (56 mg, 0.24 mmol) and potassium carbonate (55 mg, 0.40 mmol) in DMF (1 mL) was sealed in a pressure tube and heated at 80° C. overnight. The reaction mixture was diluted with water, and the resulting solid precipitate was recovered by filtration to give compound 16a. ESI-MS m/e 531.4 (M+1).

Provenance & Evidence