HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 69639794, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Phenyl chloroformate | HCID 15891 | — |
| Reactant | N-[2-Amino-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-benzyl]-3,5-dimethoxy-4-methyl-benzamide | HCID 69491883 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 69639794 | HCID 69639794 | 120.2% |
Reaction Steps
A suspension of compound 1g (100 mg, 0.26 mmol), phenyl chloroformate (0.033 mL, 0.26 mmol) and potassium carbonate (72 mg, 0.52 mmol) in DCE (2 mL) was stirred at rt overnight. Additional phenyl chloroformate (0.015 mL, 0.13 mmol) was added and the reaction was stirred at rt for 24 h. The reaction was concentrated on a rotary evaporator and the residue purified by silica gel chromotagraphy (ethyl acetate) to afford compound 19a (157 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07247654B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-da91d9b56864488bad4c1d8899d96ca4 |
| Source note | uspto-grants-2007_07 |