Aniline → HCID 69491192, compound

Participants

Reaction Steps

A solution of compound 19a (50 mg, 0.10 mmol) and aniline (0.010 mL, 0.11 mmol) in THF was heated at 60° C. for 5 h. Additional aniline (0.010 mL, 0.11 mmol) was added and the reaction was stirred at rt overnight. Additional methyl chloroformate (0.010 mL, 0.13 mmol) was added and the reaction was stirred at rt for 24 h. The solid precipitate was recovered by filtration and washed with ethyl acetate and MeOH to give compound 19b (13 mg, 26). ESI-MS m/e 502.4 (M+1).

Provenance & Evidence