HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(2-((3,5-Dimethoxy-4-methylbenzamido)methyl)-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenylamino)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | [2-[(3,5-Dimethoxy-4-methyl-benzoylamino)-methyl]-5-(5-methyl-[1,2,4]oxadiazol-3-yl)-phenylamino]-acetic acid benzyl ester | HCID 69491566 | — |
| Catalyst | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-(2-((3,5-Dimethoxy-4-methylbenzamido)methyl)-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenylamino)acetic acid | HCID 69491531 | 52% |
Reaction Steps
To a solution of compound 14a (110 mg, 0.29 mmol) in a mixture of THF (3 mL) and methanol (3 drops) was added 10% LiOH (1 mL). The reaction mixture was stirred for 5 h at rt and acidified with 1 N HCl. The resulting solid was filtered, washed with water, and dried to give compound 47a (57 mg, 52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07247654B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-3f88018816014c27919f1858a498717f |
| Source note | uspto-grants-2007_07 |