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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1296760Generated: October 30, 2026

Benzene, ((2-bromoethoxy)methyl)- → N-(2-(2-(benzyloxy)ethylamino)-4-(5-methyl-1,2,4-oxadiazol-3-yl)benzyl)-3,5-dimethoxy-4-methylbenzamide

https://huagongshe.com/reaction/1296760

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, ((2-bromoethoxy)methyl)-HCID 73833—
ReactantN-(4-(5-methyl-1,2,4-oxadiazol-3-yl)-2-(2-phenoxyethylamino)benzyl)-3,5-dimethoxy-4-methylbenzamideHCID 69489603—
ReactantN-[2-Amino-4-(5-methyl-[1,2,4]oxadiazol-3-yl)-benzyl]-3,5-dimethoxy-4-methyl-benzamideHCID 69491883—
ProductN-(2-(2-(benzyloxy)ethylamino)-4-(5-methyl-1,2,4-oxadiazol-3-yl)benzyl)-3,5-dimethoxy-4-methylbenzamideHCID 6949157351%

Reaction Steps

Compound 1g was reacted with benzyl 2-bromoethyl ether according to the procedure described in compound 42a, to give compound 51a (79 mg, 51%). ESI-MS m/e 517.4 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07247654B2
Source datasetuspto-grants-2007_07
ORD IDord-5617daa85b894a6e850df31ecfb3b3f0
Source noteuspto-grants-2007_07