Stannous Chloride → HCID 86595903, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of compound 58a (0.752 g, 2.25 mmol) in ethanol (12 mL) was added tin(II) chloride (1.62 g, 8.5 mmol). The reaction mixture was heated at 70° C. for 50 min, then cooled to rt. Saturated sodium bicarbonate solution was added. The resulting emulsion was filtered through Celite®, followed by ethyl acetate washes. The combined organic layers were washed with brine, dried, and concentrated to give compound 58b (0.57 g, 83%) as a yellow solid. ESI-MS m/e 305.5 (M+1).

Provenance & Evidence