Benzoic acid, 3-ethyl- → 2-(5-Carbamimidoyl-2-((3-ethylbenzamido)methyl)phenylamino)acetic acid

HRID 1296765Notes

Reaction equation

HRID 1296765 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]=C(C)O[N:11]=2)=[CH:6][C:5]=1[NH:16][CH2:17][C:18]([O:20]CC1C=CC=CC=1)=[O:19].[CH2:28]([C:30]1[CH:31]=[C:32]([CH:36]=[CH:37][CH:38]=1)[C:33](O)=[O:34])[CH3:29]>>[C:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][NH:2][C:33](=[O:34])[C:32]2[CH:36]=[CH:37][CH:38]=[C:30]([CH2:28][CH3:29])[CH:31]=2)=[C:5]([NH:16][CH2:17][C:18]([OH:20])=[O:19])[CH:6]=1)(=[NH:11])[NH2:14]

Participants

3

Reactant 2

HCID 96207Benzoic acid, 3-ethyl-HCID 69490392Benzyl 2-(2-(aminomethyl)-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenylamino)acetate hydrochloride

Product 1

HCID 112911792-(5-Carbamimidoyl-2-((3-ethylbenzamido)methyl)phenylamino)acetic acid

Procedure

Compound 58d was reacted with 3-ethylbenzoic acid and subsequently hydrogenated according to the procedure described in Example 58, to give Example 59. ESI-MS m/e 355.5 (M+1).

Workup

  1. customto give Example 59

Sources & evidence

ORD record
ord-166b72b2c6c746488ba25c9ee473301a
Source dataset
uspto-grants-2007_07
Patent number
US07247654B2

Reaction notes

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