3-Methylbenzoic acid → 2-(5-Carbamimidoyl-2-((3-methylbenzamido)methyl)phenylamino)acetic acid

HRID 1296766Notes

Reaction equation

HRID 1296766 reaction equation
Cl.[NH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:14]=C(C)O[N:11]=2)=[CH:6][C:5]=1[NH:16][CH2:17][C:18]([O:20]CC1C=CC=CC=1)=[O:19].[CH3:28][C:29]1[CH:30]=[C:31]([CH:35]=[CH:36][CH:37]=1)[C:32](O)=[O:33]>>[C:10]([C:7]1[CH:8]=[CH:9][C:4]([CH2:3][NH:2][C:32](=[O:33])[C:31]2[CH:35]=[CH:36][CH:37]=[C:29]([CH3:28])[CH:30]=2)=[C:5]([NH:16][CH2:17][C:18]([OH:20])=[O:19])[CH:6]=1)(=[NH:11])[NH2:14]

Participants

3

Reactant 2

HCID 74183-Methylbenzoic acidHCID 69490392Benzyl 2-(2-(aminomethyl)-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenylamino)acetate hydrochloride

Product 1

HCID 112214922-(5-Carbamimidoyl-2-((3-methylbenzamido)methyl)phenylamino)acetic acid

Procedure

Compound 58d was reacted with 3-methylbenzoic acid and subsequently hydrogenated according to the procedure described in Example 58, to give Example 60. ESI-MS m/e 341.5 (M+1).

Workup

  1. customto give Example 60

Sources & evidence

ORD record
ord-88729c36b96b40b3af5702dfcd19f2ed
Source dataset
uspto-grants-2007_07
Patent number
US07247654B2

Reaction notes

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