HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chlorobenzoic Acid → 2-(5-Carbamimidoyl-2-((3-chlorobenzamido)methyl)phenylamino)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chlorobenzoic Acid | HCID 447 | — |
| Reactant | Benzyl 2-(2-(aminomethyl)-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenylamino)acetate hydrochloride | HCID 69490392 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(5-Carbamimidoyl-2-((3-chlorobenzamido)methyl)phenylamino)acetic acid | HCID 11245355 | — |
Reaction Steps
Compound 58d was reacted with 3-chlorobenzoic acid and subsequently hydrogenated according to the procedure described in Example 58, with the exception that Raney nickel and TEA in methanol was used for the hydrogenation step, to give Example 64. ESI-MS m/e 361.5 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07247654B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-7fa9b7b87950439b856262bf53d78f9c |
| Source note | uspto-grants-2007_07 |