反应详情

A solution of 4-methyl-3-nitro-benzonitrile (3.0 g, 18.5 mmol), N-bromosuccinimide (4.12 g), and benzoyl peroxide (0.224 g) in carbon tetrachloride was refluxed overnight. The reaction mixture was diluted with dichloromethane and washed with sodium bicarbonate solution and brine, dried, and concentrated. The residue was purified by silica gel chromatography in 10% ethyl acetate hexanes to give compound 65a (2.0 g, 45%).

1. washwashed with sodium bicarbonate solution and brine
2. customdried
3. concentrationconcentrated
4. customThe residue was purified by silica gel chromatography in 10% ethyl acetate hexanes