Thionyl Chloride → 3-Quinuclidinecarbonyl chloride Hydrochloride

Participants

Reaction Steps

500 mg (2.61 mmol) of 3-quinuclidinecarboxylic acid are heated together with 1.9 ml (26.09 mmol) of thionyl chloride under reflux for 2 h. The reaction mixture is freed of excess thionyl chloride under reduced pressure. 20 ml portions of toluene are added twice and evaporated to dryness each time. The product obtained in this way is reacted immediately without further purification.

Provenance & Evidence