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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 129679Generated: October 29, 2026

5-(phenylmethoxy)-1H-indole-3-carbaldehyde → 4-Methylbenzyloxylindole-3-carboxaldehyde

https://huagongshe.com/reaction/129679

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(phenylmethoxy)-1H-indole-3-carbaldehydeHCID 81398—
ReactantN-methyl-N-phenethyl-2-(5-indolyloxy)acetamideHCID 19372247—
Reactant5-((4-Methylbenzyl)oxy)-1H-indole-3-carbaldehydeHCID 19372258—
Reactant5-(4-Methylbenzyloxy)indoleHCID 19372380—
Product4-Methylbenzyloxylindole-3-carboxaldehydeHCID 86749115—

Reaction Steps

When N-methyl-N-phenethyl-2-(5-indolyloxy)acetamide is replaced in the procedure of Example 6 with 5-benzyl-oxyindole and 5-(4-methylbenzyloxy)indole then the products obtained are 5-benzyloxyindole-3-carboxaldehyde and 5-(4-methylbenzyloxy)indole-3-carboxaldehyde. NMR confirms these structures.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05468898
Source datasetuspto-grants-1995_11
ORD IDord-eed06a9c2f9c4578a77cd8b85477ad26
Source noteuspto-grants-1995_11