Water → HCID 178503545, compound

Participants

Reaction Conditions

Reaction Steps

The suspension of 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-thioxo-thiazolidin-4-one (2.2 g, 8.22 mmol), iodomethane (1.05 mL, 16.8 mmol) and DIEA (3.0 mL, 16.8 mmol) in anhydrous ethanol (110 mL) was stirred at 100° C. for 2 h. After adding water (200 mL), the solid was collected by filtration, washed with water and dried to obtain 2-methylsulfanyl-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-thiazol-4-one (1.48 g, 60.8%) as a grey solid. LC-MS m/e 276 (MH+).

Provenance & Evidence