反应详情

A mixture of 0.93 g of N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyvinyl)indol-1-yl]acetamide, 0.5 g of 10% palladium on activated carbon and 150 ml of ethanol is shaken under 40 psi of hydrogen on a Parr Apparatus for 40 minutes. The mixture is filtered to remove the catalysts and the filtrate is concentrated in vacuo. The residue is purified by dry column chromatography over silica gel eluting with a solvent system of ethyl acetate/hexane (2:1, v/v) to give N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carbethoxyethyl)indol-1-yl]acetamide as white powder (m.p. 81°-83° C.).

1. filtrationThe mixture is filtered
2. customto remove the catalysts
3. concentrationthe filtrate is concentrated in vacuo
4. customThe residue is purified
5. dry with materialby dry column chromatography over silica gel eluting with a solvent system of ethyl acetate/hexane (2:1