1-Methylpyrrolidine → HCID 22020309, compound

Participants

Reaction Conditions

Reaction Steps

141.13 g (1.657 mol) of 1-methylpyrrolidine in 800 ml of dry hexane are introduced into a round-bottomed flask fitted with a reflux condenser. 272 g (1.657 mol) of methyl triflate are added over the course of 45 minutes with constant stirring and cooling with the aid of an ice bath. The ice bath is then replaced by an oil bath, and the reaction mixture is refluxed for 15 minutes (oil-bath temperature 70-75° C.). After cooling to room temperature, the white precipitate is filtered off, washed twice with 100 ml of hexane and dried at 110° C. under a 30-100 Pa vacuum for three hours, giving 409 g (yield: 99.1%) of 1,1-dimethylpyrrolidinium trifluoromethanesulfonate as a white solid.

Provenance & Evidence