HRID129683

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)C=Cc1cn(CC(=O)N(C)CCc2ccccc2)c2ccc(OCc3ccccc3)cc12

HCID53736924

未命名化合物

结构：C=CC(=Cc1cn(CC(=O)N(C)CCc2ccccc2)c2ccc(OCc3ccccc3)cc12)C(=O)O

HCID53760680

未命名化合物

结构：CCOC(=O)C(C)=Cc1cn(OCc2ccccc2)c2ccc(CC(=O)N(C)CCc3ccccc3)cc12

HCID54354901

未命名化合物

PRODUCTS

生成物

结构：CN(CCc1ccccc1)C(=O)Cn1cc(C=CC=CC(=O)O)c2cc(OCc3ccccc3)ccc21

HCID53773500

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21584533

Acetone diethylether

C7H16O2

PROCEDURE

实验过程

When N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboethoxyvinyl)-indol-1-yl]acetamide in the procedure of Example 23 is replaced with N-methyl-N-phenethyl-2-[1-benzyloxy-3-(2-carbethoxy-2-methylvinyl)indol-5-yl]acetamide then the product prepared is N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-carboxy-1,3-butadienyl)indol-1-yl]acetamide. (solvent system (acetone/ether) m.p. 189°-190° C.)

WORKUP

后处理

customthe product prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bd45b897922d43b99bb2b0c2e44457dd
来源数据集: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05468898
来源说明: uspto-grants-1995_11

反应 SMILES

[CH3:1][N:2]([CH2:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[C:3](=[O:29])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][CH:12]=2)[C:7]([CH:22]=CC(OCC)=O)=[CH:6]1.CN(CCC1C=CC=CC=1)C(=O)CC1C=C2C(=CC=1)N(OCC1C=CC=CC=1)C=[C:45]2[CH:59]=[C:60]([C:62]([O:64]CC)=[O:63])C.CN(CCC1C=CC=CC=1)C(=O)CN1C2C(=CC(OCC3C=CC=CC=3)=CC=2)C(C=C(C(O)=O)C=C)=C1>CC(C)=O.CCOCC>[CH3:1][N:2]([CH2:30][CH2:31][C:32]1[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1)[C:3](=[O:29])[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][C:10]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[CH:11][CH:12]=2)[C:7]([CH:22]=[CH:45][CH:59]=[CH:60][C:62]([OH:64])=[O:63])=[CH:6]1