Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

0.93 g of cinacalcet base was dissolved in 50 ml of n-heptane at room temperature. Then, HCl gas was bubbled into the solution, producing a precipitate. The HCl gas was added until no more precipitation was observed. The resulting slurry was then stirred at room temperature for 0.5 hour. The product was isolated by filtration, washed with 10 ml of n-heptane, and dried at 50° C. in a vacuum oven for 17 hours, yielding 0.75 g of cinacalcet hydrochloride crystalline Form I.

Provenance & Evidence