Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

0.8 g of cinacalcet base was dissolved in 50 ml of n-hexane at room temperature. Then, HCl gas was bubbled into the solution, producing a precipitate. The HCl gas was added until no more precipitation was observed. The resulting slurry was stirred at room temperature for 20 minutes. The product was isolated by filtration, washed with 10 ml of n-Hexane, and dried at 50° C. in a vacuum oven for 17 hours, yielding 0.76 g of cinacalcet hydrochloride crystalline Form I.

Provenance & Evidence