Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

0.3 g of cinacalcet base was dissolved in 6 ml of diethyl ether at room temperature, i.e., about 20° to about 25° C. Then, 3 ml of 1N HCl were added to the solution in one portion, resulting in an immediate precipitation. The resulting slurry was stirred at room temperature, i.e., about 20° to about 25° C., overnight. The product was isolated by filtration, washed with 5 ml of diethyl ether, and dried at 50° C. in a vacuum oven for 24 hours, yielding 0.26 g of cinacalcet hydrochloride crystalline Form I.

Provenance & Evidence