Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

1.0 g of cinacalcet base was partially dissolved in 30 ml of n-pentane at room temperature. Then, HCl gas was bubbled into the solution, producing a precipitate. The HCl gas was added until no more precipitation was observed. The resulting slurry was stirred at room temperature for 0.5 hour. The product was isolated by filtration, washed twice with 25 ml of n-pentane, and dried at 50° C. in a vacuum oven for 16 hours, yielding 0.87 g of cinacalcet hydrochloride crystalline Form I.

Provenance & Evidence