Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

2.2 grams of cinacalcet base was dissolved in 2 ml of acetone at room temperature. Then, 10 ml of 1N HCl was added in one portion and the mixture was stirred at room temperature for 1 hour, yielding a precipitate. The product was isolated by filtration, washed with 10 ml of water, and dried at 50° C. in a vacuum oven for 24 hours, providing 1.75 grams of cinacalcet hydrochloride crystalline Form I. Purity: 99.9 HPLC area percent.

Provenance & Evidence