Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

0.49 g cinacalcet base was dissolved in 10 ml of toluene at room temperature, i.e., about 20° to about 25° C. Then, 2 ml of 1N HCl was added in one portion, and the resulting mixture was stirred at room temperature overnight, yielding a precipitate. The product was isolated by filtration, washed with 10 ml of toluene, and dried at 50° C. in a vacuum oven for 17 hours, yielding 0.02 g of cinacalcet hydrochloride crystalline Form I.

Provenance & Evidence