Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | HCID 54514586 | HCID 54514586 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178483180 | HCID 178483180 | — |
Reaction Steps
A suspension of 0.94 g (2 mmoles) of N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-cyanovinyl)indol-1-yl]acetamide, 0.56 g (10.45 mmoles)of ammonium chloride and 0.68 g (10.45 mmoles) of sodium azide in 20 ml of dimethyl-formamide is heated at 100° C. for 18 hours. The mixture is poured into ice water. Addition of ethyl acetate gives a precipitate which is collected and triturated in acetone to give N-methyl-N-phenethyl-2-[5-benzyloxy-3-(2-tetrazol-5-yl)vinylindol-1-yl]acetamide. (m.p. 203°-205° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05468898 |
|---|
| Source dataset | uspto-grants-1995_11 |
|---|
| ORD ID | ord-a725700d18b94f688563a8c957afa893 |
|---|
| Source note | uspto-grants-1995_11 |
|---|
