Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

1.2 g of cinacalcet base was stirred in 20 ml of MTBE at room temperature. Then, 10 ml of 1N HCl was added in one portion. Precipitation occurred immediately. The mixture was stirred at room temperature for 4 hours. The product was isolated by filtration, washed with 5 ml of MTBE, and dried at 50° C. in a vacuum oven for 16.5 hours, yielding 0.58 g of cinacalcet hydrochloride crystalline Form I.

Provenance & Evidence