Hydrochloric Acid → Cinacalcet Hydrochloride

Participants

Reaction Steps

0.75 g of cinacalcet base was dissolved in 3 ml of absolute ethanol at room temperature. Then, 14 ml of 1N HCl was added drop-wise to the solution and the resulting mixture was stirred at room temperature for 3.5 hours to obtain a precipitate. The product was isolated by filtration, washed with 2 ml of water, and dried at 50° C. in a vacuum oven for 17 hours, yielding 0.5 g of cinacalcet hydrochloride crystalline Form I.

Provenance & Evidence