Methyl 5-(Benzyloxy)-1H-indole-2-carboxylate → HCID 19372248, compound

HRID 129686Notes

Reaction equation

HRID 129686 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13]([C:18]([O:20][CH3:21])=[O:19])=[CH:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:22][N:23]([CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24](=[O:27])[CH2:25]Br>>[CH3:22][N:23]([CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)[C:24](=[O:27])[CH2:25][N:14]1[C:15]2[C:11](=[CH:10][C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:17][CH:16]=2)[CH:12]=[C:13]1[C:18]([O:20][CH3:21])=[O:19]

Participants

3

Reactant 2

HCID 4777669Methyl 5-(Benzyloxy)-1H-indole-2-carboxylateHCID 10753531N-methyl-N-phenethyl-2-bromoacetamide

Product 1

HCID 19372248HCID 19372248, compound

Procedure

Following the procedure of Example 10, 5-benzyloxy-2-carbomethoxyindole is alkylated with N-methyl-N-phenethyl-2-bromoacetamide to give N-methyl-N-phenethyl-2-(5-benzyloxy-2-carbomethoxyindol-1-yl)acetamide. (m.p. 155°-156° C.)

Sources & evidence

ORD record
ord-077978ff7a7345a7bf7b14f9608af743
Source dataset
uspto-grants-1995_11
Patent number
US05468898

Reaction notes

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