N-Methylbenzeneethanamine → N-methyl-N-phenethyl-2-(5-benzyloxyindol-3-yl)acetamide

HRID 129687Notes

Reaction equation

HRID 129687 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH2:18][C:19]([OH:21])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:22][NH:23][CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH3:22][N:23]([CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[C:19](=[O:21])[CH2:18][C:12]1[C:11]2[C:15](=[CH:16][CH:17]=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:10]=2)[NH:14][CH:13]=1

Participants

3

Reactant 2

HCID 11503N-MethylbenzeneethanamineHCID 963405-Benzyloxyindole-3-acetic acid

Product 1

HCID 19372283N-methyl-N-phenethyl-2-(5-benzyloxyindol-3-yl)acetamide

Procedure

When the procedure of Example 14 is followed, 5-benzyloxyindole-3-acetic acid and N-methyl-N-phenethylamine are reacted to give N-methyl-N-phenethyl-2-(5-benzyloxyindol-3-yl)acetamide. (m.p. 146° C. (dec.))

Sources & evidence

ORD record
ord-af5cea999f7d402a859e1a501f9cb697
Source dataset
uspto-grants-1995_11
Patent number
US05468898

Reaction notes

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