Phenylacetic Acid → 6-Ethyl-7-hydroxy-3-phenyl-chromen-4-one

Participants

Reaction Steps

This compounds was synthesised in the same manner as described above. Ethyl resorcinol (0.83 g, 6 mmol), phenylacetic acid (0.82 g, 6 mmol), BF3Et2O (3.88 ml, 31.5 mmol), PCl5 (1.88 g, 9 mmol), DMF (4.6 ml and 10 ml). The precipitate formed was filtered and re-crystallized from methanol to give 6-Ethyl-7-hydroxy-3-phenyl-chromen-4-one as a pale brown solid (1.4 g, 87.7%); Rf 0.4 cf SM 0.5 ethyl acetate/hexane (40/60).

Provenance & Evidence