Dimethylformamide → 3-(4-bromophenyl)-6-ethyl-7-hydroxy-4H-chromen-4-one

Participants

Reaction Steps

This compounds was synthesised in the same manner as described above. Ethyl resorcinol (0.83 g, 6 mmol), 4-bromophenylacetic acid (1.29 g, 6 mmol), BF3Et2O (5 ml), PCl5 (1.99, 9.1 mmol), DMF (5 ml and 10 ml). The precipitate formed was filtered and re-crystallized from methanol to give 3-(4-bromo-phenyl)-6-ethyl-7-hydroxy-chromen-4-one as a pale pink solid (1.7 g, 82.3%); Rf 0.84 ethyl acetate.

Provenance & Evidence