Dimethylformamide → 3-(3,4-Dimethoxy-phenyl)-6-ethyl-7-hydroxy-chromen-4-one

Participants

Reaction Steps

This compounds was synthesised in the same manner as described above. Ethyl resorcinol (0.83 g, 6 mmol), 3,4-dimethoxyphenylacetic acid (0.83 g, 6 mmol), BF3Et2O (4 ml), PCl5 (1.9 g, 9.1 mmol), DMF (5 ml and 10 ml). The precipitate formed was filtered and re-crystallized from methanol to give 3-(3,4-dimethoxy-phenyl)-6-ethyl-7-hydroxy-chromen-4-one as a pale brown solid (1.8 g, 92%); Rf 0.4 cf SM 0.5 ether/petroleum ether [40–60° C.] (50/50).

Provenance & Evidence