4-Chlororesorcinol → HCID 58913601, compound

Participants

Reaction Steps

This compound was synthesised in the same manner as described above. 4-Chlororesorcinol (0.37 g, 2.58 mmol), [3-(4-Cyano-butoxy)-phenyl]-acetic acid (0.6 g, 2.58 mmol), BF3Et2O (8 ml), PCl5 (0.81 g, 3.89 mmol), DMF (8 ml and 12 ml). The precipitate formed was filtered and re-crystallized from methanol to give 5-[3-(6-Chloro-7-hydroxy-4-oxo-4H-chromen-3-yl)-phenoxy]-pentanenitrile as a white solid (0.59 g, 59.1%); Rf 0.7 ethyl acetate/hexane (80/20)].

Provenance & Evidence