4-Chlororesorcinol → HCID 58913673, compound

Participants

Reaction Steps

This compounds was synthesised in the same manner as described in Section 1.1.4.1. 4-Chlororesorcinol (0.37 g, 2.58 mmol), [[4-(4-Cyano-butoxy)-phenyl]-acetic acid (0.6 g, 2.28 mmol), BF3Et2O (5 ml), PCl5 (0.81 g, 3.89 mmol), DMF (8 ml and 12 ml). The precipitate formed was filtered and re-crystallized from methanol to give 5-[4-(6-Chloro-7-hydroxy-4-oxo-4H-chromen-3-yl)-phenoxy]-pentanenitrile as a white solid (0.63 g, 66.2%); Rf 0.65 ethyl acetate/hexane (80/20)].

Provenance & Evidence