Hydrazine hydrate (1:1) → HCID 178511054, compound

Participants

Reaction Steps

This compounds was synthesised in the same manner as described above. 4-[2-(6-Chloro-7-hydroxy-4-oxo-4H-chromen-3-yl)-phenoxy]-butyronitrile (0.1 g, 0.28 mmol), Hydrazine hydrate (6 ml). The quenched reaction was extracted into ethyl acetate, washed (water), dried (MgSO4), and the solvent removed under vacuum to give a clear oil which was purified by column chromatograpy to give 4-{2-[3-(5-chloro-2,4-dihydroxy-phenyl)-1H-pyrazol-4-yl]-phenoxy}-butyronitrile as an off white soild Rf 0.65 ethyl acetate/hexane (70/30).

Provenance & Evidence