Water → HCID 58913633, compound

Participants

Reaction Steps

N-Chlorosuccinimide (0.27 g, 2 mmol) was added to a solution of 6-chloro-7-hydroxy-3-(4-methoxy-phenyl)-2-methyl-chromen-4-one (0.29 g, 1 mmol) in DMF (4 ml) and the solution stirred for 3 hrs. and at 50° C. for ˜3 hrs. The resulting solution was poured into water (50 ml) and extracted with ethyl acetate (2×30 ml). The combined extracts were washed with water (5×50 ml) and saturated aqueous sodium chloride solution (30 ml). The solution was dried over anhydrous magnesium sulphate and concentrated to give a dark yellow oil. Trituration with hexane gave 6,8-dichloro-7-hydroxy-2-methyl-3-phenyl-chromen-4-one as a pale orange powder, dried in vacuo, (0.19 g)

Provenance & Evidence