N-Iodosuccinimide → HCID 178477918, compound

Participants

Reaction Steps

To a mixture of 3-(2,4-bis-benzyloxy-5-chloro-phenyl)-1H-pyrazole (4.06 g 10.05 mmol) in DCM (50 ml) was added N-iodosuccinimide (2.35 g, 10.45 mmol) in bulk. The mixture was stirred at room temperature for two hours and then partitioned between water and DCM. The organics were washed with saturated sodium thiosulphate solution then water and dried in vacuo to give a yellow crystalline mass, which was triturated from ethyl acetate by the gradual addition, whilst stirring, of hexanes to give 3-(2,4-bis-benzyloxy-5-chloro-phenyl)-4-iodo-1H-pyrazole (5.21 g, 97%).

Provenance & Evidence