4-Methoxyphenylacetic Acid → HCID 58913540, compound

Participants

Reaction Steps

A solution of 4-chloro-2-methyl-benzene-1,3-diol (1 eq) and p-methoxy phenyl acetic acid (1 eq) in boron trifluoride diethyl etherate (8 eq) was refluxed for 5 h, whilst stirring, under nitrogen. The solution was allowed to cool to room temperature, quenched with 10% NaOAc (aq) and left to stand overnight. The resultant precipitate was filtered, washed with water and dried to give 1-(5-chloro-2,4-dihydroxy-3-methyl-phenyl)-2-(4-methoxy-phenyl)-ethanone as a solid.

Provenance & Evidence