Hydrazine hydrate (1:1) → HCID 136049316, compound

Participants

Reaction Steps

6-Chloro-3-(4-methoxy-phenyl)-2,8-dimethyl-4H-chromene-4,7-diol (1 eq) was taken up in a 1:1 solution of EtOH:Hydrazine hydrate and heated under microwave conditions (120° C., 300 sec). The solution was concentrated in vacuo, residue quenched with cold water, extracted with ethyl acetate and purified by flash chromatography (neat DCM). The yellow oil was then triturated with ether:hexane to give 4-chloro-6-[4-(4-methoxy-phenyl)-5-methyl-1H-pyrazol-3-yl]-2-methyl-benzene-1,3-diol as a solid.

Provenance & Evidence