HCID 19372339, compound → HCID 10712813, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.08 g (0.24 mmol) of 1-hydroxyethyl-3-carbomethoxy-6-benzyloxynaphthalene in 10 ml of acetone at 0° C. is added Jones reagent until a green precipitate forms. After stirring at 0° C. for 10 minutes, the mixture is partitioned between ethyl acetate and H2O. The organics are dried (MgSO4) and concentrated in vacuo to afford 0.081 g of 3-carbomethoxy-6-benzyloxy-1-naphthyl acetic acid in the form of a light tan solid which is used directly in the next step.

Provenance & Evidence