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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1296964Generated: October 29, 2026

Hydrochloric Acid → (S)-2-(3-{3-[(2-Chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid hydrochloride salt

https://huagongshe.com/reaction/1296964

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant(S)-2-(3-{3-[[2-Chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic AcidHCID 10289391—
SolventDiethyl EtherHCID 3283—
Product(S)-2-(3-{3-[(2-Chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid hydrochloride saltHCID 6881712399%

Reaction Steps

To a solution of the (S)-2-(3-{3-[[2-chloro-3-(trifluoromethyl)benzyl](2-phenyl-propyl)amino]propoxy}-phenyl)acetic acid in ethyl ether was added HCl in diethyl ether (1.0M).The suspension was filtered and dried to give the title compound as a white solid (99%). NMR(400 MHz, CD3OD) δ: 8.0 (d, J=4.0Hz, 1H), 7.9 (d, J=4.0Hz, 1H), 7.7–7.3 (m, 7H), 7.1 (d, J=8.0 Hz, 1H), 6.8 (m, 2H), 4.1–3.4 (m, 11H), 2.3 (m, 2H), 1.5 (d, J=4.0 Hz, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07247748B2
Source datasetuspto-grants-2007_07
ORD IDord-db673657c20c40dbabc0b66dbfc1de5e
Source noteuspto-grants-2007_07