Hydrochloric Acid → 3-[2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy)phenyl)-ethanoylamino]-propionic acid hydrochloride salt

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Reaction Steps

To a stirring solution of 3-[2-(3-{3-[(2-Chloro-3-trifluoromethyl-benzyl)-diphenylethyl-amino]-propoxy}-phenyl)-ethanoylamino]-propionic acid tert-butyl ester (110 mg, 0.15 mmol) in Et2O (5 mL) was added 1M HCl in Et2O (0.46 ml, 0.46 mmol). The mixture was stirred at room temperature for 18 hours. Purification by preparative HPLC (YMC, 75×30 mm, 25 ml/min, 40–100% CH3CN:H2O) afforded the desired carboxylic acid. Treatment of the tertiary amine/carboxylic acid with 1 N HCl (Et2O) followed by concentration in vacuo afforded the title compound as a yellow solid (84 mg, 79%). MS(ES) m/e 653.4 (M+).

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